Alkali replacement raises urinary citrate excretion in patients with topiramate-induced hypocitraturia
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چکیده
منابع مشابه
24 Hour Urinary Citrate Levels and Frequency of Hypocitraturia among Patients with Recurrent Nephrolithiasis
Background: Nephrolithiasis is a common disorder with high rate of prevalence and recurrence without treatment. Urinary citrates, among others are important inhibitors of stone formation. The mean urinary citrate excretion is 640mg/d in healthy individuals. Hypocitraturia is a common metabolic abnormality detected in stone formers. Aim: To determine frequency of hypocitraturia among patients wi...
متن کاملStudy of urinary acidification in patients with idiopathic hypocitraturia.
Hypocitraturia (HCit) is one of the most remarkable features of renal tubular acidosis, but an acidification defect is not seen in the majority of hypocitraturic patients, whose disease is denoted idiopathic hypocitraturia. In order to assess the integrity of urinary acidification mechanisms in hypocitraturic idiopathic calcium stone formers, we studied two groups of patients, hypocitraturic (H...
متن کاملUrinary citrate in kidney stone disease.
BACKGROUND Hypocitraturia, or low urinary citrate excretion is known as a risk for nephrolithiasis. Though urinary citrate excretion is basically determined by acid-base balance, metabolic acidosis is not always manifest in urinary stone patients with hypocitraturia. From our stone clinic data, we estimated the incidence of hypocitraturia and addressed its causes in the absence of obvious acid-...
متن کاملAdenosine Triphosphate Citrate Lyase in Hypocitraturia
Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundan...
متن کاملAssociation of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration
Urinary citrate (Ucit) protects against urinary stone formation. Acid base status and diet influence Ucit. However, the effect of demographics, diet, and glucose metabolism on Ucit excretion, urinary pH (U-pH) and net gastrointestinal alkali absorption (NAA) are not known. Twenty-four hour urine samples, blood glucose, creatinine, and cystatin C were obtained from non-Hispanic white sibships in...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2015
ISSN: 0306-5251
DOI: 10.1111/bcp.12751